As reward, Gattilusio was given lordship of the island of Lesbos (and its stronghold, Mytilene) from July 1355, as well as the hand in marriage of the emperor's sister, Maria.

[3] The Gattilusi possessions grew to include, among others, the islands of Imbros, Samothrace, Lemnos and Thasos, and the mainland city of Aenos (modern Enez in Turkey).

In 1456, the Ottomans appointed a native Greek historian, Michael Critobulus, as governor of Imbros, and likewise removed the Gattilusi from power in the remainder of their possessions, with the exception of Lesbos, which they were permitted to retain in return for an annual payment of 4,000 gold pieces.

[6] Archaeological excavations in the castle of Mytilene since 1984 by the University of British Columbia under the direction of Caroline and Hector Williams have uncovered the burial chapel of the Gattilusi and a few graves that probably belonged to dependents of the family.

The Canadian excavations have also added a considerable number of Gattilusi coins to the known corpus, now published by Dr. Robert Weir[citation needed]