[5] In 1911, Squires co-founded the Mesquite Club, which was formed to "cover a broad area of endeavors of social, civic, and philanthropic importance".

[6][7] In 1914, Squires served as the Nevada state representative for the General Federation of Women's Clubs, attending the Twelfth Biennial Convention held in Chicago.

She was noted for her presidential address where she cited the 2 million members of the federation "with its influence and an ability to vote, how women could begin to change society".

[9] Squires is remembered for following a 'diplomatic approach' to securing a woman's right to vote, departing from the more radical ways of activists Anne Martin and Bird Wilson.

[10] The efforts of Squires and the Mesquite Club in fighting for the Nineteenth Amendment is commemorated by a historical marker in downtown Las Vegas.