Delta Phi Omega (commonly referred to as DPO, or ΔΦΩ) is a nationally-based, South Asian-interest, multicultural sorority in the United States.

It is a social, service, and philanthropy-based Greek letter organization whose main focus is to empower women and promote cultural awareness through involvement with their universities and communities.

On December 6, 1998, sixteen South Asian women formed Delta Phi Omega at the University of Houston.

The sixteen Honorable National Founding Mothers are: Delta Phi Omega was envisioned as an organization that would focus on the diverse Indian culture through participation in various community and service projects, promote the advancement of South Asian women, and unite women in the South Asian community.

In 2001, sisters foresaw a rapid expansion of Delta Phi Omega and recognized the need for a central governing body.

Its functions also include handling matters of controversy, coordinating national-level programs, and overseeing chapter compliance with national policies.