[citation needed] Andrade initially struggled at the international level, losing to Eastern Europe opponents at the World Cup in 2005 and 2006.

[2] He won gold at the 2007 World Amateur Boxing Championships, where he beat Kakhaber Zhvania, Dmitrijs Sostaks, 2005 silver medalist Magomed Nurutdinov, future champion Jack Culcay-Keth, and Adem Kılıççı in the semifinal round.

He overcame Kakhaber Zhvania and the highly regarded Russian Andrey Balanov 14:3 to advance to the quarterfinals but he was shocked by Korean veteran Kim Jung-Joo 9:11 (Olympic results) in a controversial loss.

Though unable to win an Olympic Gold Medal that year, Andrade decided to end his exceptional amateur campaign and become a professional.

An opportunity arose in the Summer of 2013 when the vacant WBO light middleweight title would be decided by one match between Andrade and Armenian contender Vanes Martirosyan (33–0–1, 21 KOs).

[8] On March 20, 2014 it was confirmed that British boxer and mandatory challenger Brian Rose (25–1–1, 7 KO) would be the first defence of Andrade's world title reign.

[12][13] Andrade put in a dominant performance to claim his place as a top champion in order to lure a future fight with the division best including Canelo Álvarez and Floyd Mayweather.

[15] Andrade was scheduled to fight Jermell Charlo (24–0, 11 KOs) at Mandalay Bay Resort & Casino on December 13, 2014, defending his WBO title.

[27] On September 16, 2015 Banner Promotions and Star Boxing announced that Andrade would return to the ring after 16 months of inactivity against 28 year old Argentine boxer Dario Fabian Pucheta (20-2, 11 KOs) for the vacant WBA International light middleweight title at the Mohegan Sun Casino in Uncasville, Connecticut on October 17.

[29][30] ESPN reported that Andrade would take part in a Showtime-televised tripleheader in a WBC light middleweight final eliminator against 28 year old contender Willie Nelson (25–2–1, 15 KOs) on June 11, 2016 at the Turning Stone Resort & Casino in Verona, New York.

"[33][34] Andrade, although he was mandatory for Jermell Charlo's WBC title, made it known that he was also targeting a fight with long-time WBA 'super' champion Erislany Lara (23–2–2, 13 KOs), who was also regarded one of the best at 154 pounds.

"[36] Andrade agreed terms to fight Jack Culcay (22–1, 11 KOs) for the WBA 'Regular' light middleweight title at the MBS Arena in Potsdam, Brandenburg on November 5, 2016.

[42][43][44] On September 14, 2017 it was announced that Andrade would appear on a HBO card, as part of his new multi-fight deal on October 21 as a co-feature to Jezreel Corrales vs. Alberto Machado at the Turning Stone in Verona, New York.

[52] On June 20, 2018 it was reported by ESPN's Dan Rafael that HBO would air Andrade against 2012 Olympic bronze medalist Yamaguchi Falcão (15-0, 7 KOs) on the undercard of Jaime Munguía's WBO light middleweight title defence against Liam Smith on July 21 at the Hard Rock Hotel & Casino in Las Vegas.

[55][56] On July 12, the WBO ordered Billy Joe Saunders (26-0, 12 KOs) to make a mandatory defence against Andrade, with both sides having 10 days to reach a deal.

Hearn stated he would wait to see if the Massachusetts commission will allow Saunders to fight, however confirmed Andrade would still appear in the main event, whether it be a vacant world title or a non-title bout.

[72] In front of 6,874 in attendance, Andrade became a two-weight world champion, capturing the vacant WBO title after he dropped Kautondokwa four times in the fight en route to winning via unanimous decision.

[75] On December 21, 2018 Matchroom Boxing announced Andrade would make the first defence of his newly won WBO belt against Russian boxer Artur Akavov (19-2 8 KOs) at the Hulu Theater at Madison Square Garden in New York on January 18, 2019, live and exclusive on DAZN.

It was seemingly a premature stoppage by referee Arthur Mercante Jr., who stopped the fight after Andrade caused Akavov to lose balance against the ropes after landing a right hook followed by a body shot.

[95] On October 3, 2019 the WBO ordered Andrade and his team to enter the 30 day negotiations with mandatory challenger, 24 year old Steven Butler (28-1-1, 24 KOs).

Although Hearn did not confirm the date or opponent, he was rumoured to fight Irish boxer Luke Keeler (17-2-1, 5 KOs), ranked #3 by the WBO and #10 by the IBF at middleweight.

[98][99] On December 12, the card was formally announced to take place at Meridian at Island Gardens in Miami, Florida on January 30, 2020, a Thursday.

It was revealed that Hearn offered promotional-free Jermall Charlo, who was affiliated with Premier Boxing Champions, a deal worth $7 million, a career-high, to fight Andrade, which was snubbed.

[141] Andrade made a big statement on fight night knocking out Quigley in round 2, retaining his world title for a fifth and final time.

We can’t just keep taking [low level] fights.” Hearn's aim with Andrade was always to get him a big money fight, even if that now meant vacating a world title to make that happen.

[160] Andrade post a video to social media where he criticized Chris Eubank Jr. after he declined to accept an offer of over one million dollars to fight him.

[168] On December 5, Andrade was added to the undercard of the Gervonta Davis vs. Hector Luis Garcia Showtime PPV on January 7, 2023 from the Capital One Arena in Washington, D.C.

In the fifth round, Nicholson appeared to drop Andrade for a flash knockdown with a body shot, however, it was ruled a slip by the referee Malik Waleed.

[177] According to ESPN's Mike Coppinger in August 2023, a deal between Andrade and former world champion David Benavidez (27-0, 23 KOs) was being finalised with a target date before the end of the year.

[178][179][180] On October 1, the fight and card was confirmed to take place on Showtime PPV, on November 25 at the Frost Bank Center in San Antonio, Texas.