It was a highly regarded journal meant to champion Jacksonian Democracy, a movement which had usually been disparaged in the more conservative North American Review.
The magazine featured political essays, many of them penned by O'Sullivan himself, extolling the virtues of Jacksonian democracy and criticizing what Democrats regarded as the aristocratic pretensions of their opponents.
Its editorials and articles provided the arguments that partisan needed to discuss Democratic Party positions on the Mexican War, slavery, states' rights, and Indian removal.
The Review also published some of the early work of Walt Whitman, James Russell Lowell, and Henry David Thoreau.
The magazine is also responsible for coining the term "manifest destiny", referring to the combination of rapid growth of civilization and open space to grow in North America.