The Great Western Main Line between Reading and Swindon runs through the parish just south of the village, but there is no station.

Denchworth manor was assessed at half a knight's fee and had been let to Henry de Tubney by the middle of the 13th century.

[2] Denchworth parish also included a manor that in the 12th century was called Suthcote — a toponym derived from the fact that it is south of the village.

This manor existed by 947, when King Eadred granted an estate of five hides there to one Wulfric, who conveyed it to Abingdon Abbey.

The Abbey retained the overlordship of Circourt until the Dissolution of the Monasteries in the 16th century,[2] when it was forced to surrender all its estates to the Crown.

His son Sir Charles Saxton, 2nd Baronet was Member of Parliament for Cashel 1812–18 and held the manor in 1824.

[2] The Domesday Book records a manor of six hides at South Denchworth held by one Laurence of Wilbrighton in Staffordshire.

His heirs became the Wilbrighton family, and by 1241 they had divided the manor and granted half to the Augustinian Poughley Priory.

[2] The earliest recorded ancestor of the Hyde family in Denchworth parish was one Warin, who lived there in the middle of the 13th century.

One of the Geerings then sold it to the Moyer family, from whom it passed by marriage to John Heathcote of Connington Castle.

In 1327 Robert de la Rivere granted seisin of all the family's lands at South Denchworth to John Loveday.

Denchworth's medieval manor house in the village had a large moat, part of which is still in water.

[8] The chancel, north chapel and possibly the south transept were rebuilt in the 15th century,[2] mostly with Perpendicular Gothic windows.

It replaces a two-storey south porch, in whose upper room Gregory Geering and the then vicar established an antiquarian chained library.

[2] Its contents included a 1483 edition of the Golden Legend that is now in the Bodleian Library in Oxford and other rare volumes that were transferred to Denchworth vicarage.

One of the inscriptions for William and Margery Hyde has a commemorative plaque for the foundation of Bisham Priory in 1333 on the back.

[11] At the junction of Brook Lane and Hyde Road is the base and broken shaft of a 14th or 15th century preaching cross.

A sum of £53 13s 2d in British government consols was added to this after Denchworth's common lands were enclosed in 1806.

The school building and schoolteacher's house were designed by the Oxford Diocesan Architect George Edmund Street and built in 1853.