Denervation

The three primary categories of nerve injury are neurapraxia, axonotmesis, and neurotmesis, each corresponding to varying degrees of damage and potential for recovery.

[9] Much like post-polio syndrome, ALS also has similar symptoms of motor neurodegeneration leading to general weakness and, in some cases, paralysis.

Renal denervation involves using radio frequency or ultrasound to eliminate the sympathetic nerve supply to the kidney wall, aiming to lower blood pressure and treat chronic hypertension.

[11] Renal denervation has become less common in recent years due to new evidence indicating that the procedure does not significantly lower blood pressure.

[14] In a vagotomy, the vagus nerve is surgically removed to treat peptic ulcer disease by reducing stomach acid.

This entrapment or compression can be diagnosed based on multiple factors including physical examination, electrodiagnostic test and clinical history.

Ultrasonography is advantageous with the evaluation of peripheral nerve resolutions while Magnetic Resonance Imaging is more sensitive in regard to signal intensity changes of the muscle.

[17] Denervation affects the muscle activation process that is brought on by the development and propagation of an action potential and the ensuing release of calcium.

home-based functional electrical stimulation has been shown to rescue muscles which have experienced severe atrophy as a result of denervation.

[citation needed] For muscles that cannot be rescued via home-based functional electrical stimulation, an Italian study suggests that, at some point in the future, the following techniques may be applicable: they must first have induction and separation of autologous myogenic cells.

This magnified image of type 2 muscle fibers shows denervation atrophy occurring at the white spaces at the top left and bottom center of the image. The white space represents a disruption of the nerve fibers, resulting in a loss of nerve supply to the muscle fibers.