His first job in pathology was at the Brompton Hospital at the time that the first clinical trial with a randomised intake between treatment of pulmonary tuberculosis (TB) with streptomycin or with bed rest alone was run.
The framework of this work was a series of clinical trials in the UK and in larger numbers in East Africa, India, Hong Kong, Singapore and Czechoslovakia.
This work passed through two stages; the first dealt with the problem of drug-resistant tubercle bacilli, which was solved by the use of regimens incorporating 2, 3 or 4 different anti-tuberculosis drugs.
After his notional[3] retirement in 1985, he continued working first at the Royal Postgraduate Medical School, Hammersmith and then at St George's, University of London.
More recently he developed a new type of phase II 8-week study using modelling of counts of TB in sputum during treatment (with Geraint Davies and the South African MRC).