Born in Fivizzano, Verdini graduated in Political Sciences from the University of Florence and later became president of the local cooperative bank, Credito Cooperativo Fiorentino.

In 2009, after Berlusconi created The People of Freedom, he was named a member of the national coordination office, together with Ignazio La Russa and Sandro Bondi.

On 23 July 2010 he resigned as president of Credito Cooperativo Fiorentino following his involvement in the so-called "P3" scandal,[2] in which he had been charged for participating in illegal secret activities, aiming to influence the verdict of the Italian Constitutional Court regarding the Lodo Alfano (the law was later declared anti-constitutional).

In July 2015, Verdini left Forza Italia and founded a new political party, the Liberal Popular Alliance, in support of Matteo Renzi's government.

In March 2016, Verdini was sentenced by the Seventh Criminal Chamber of the Court of Rome to two years' imprisonment for complicity in corruption relating to the renovation of the School of Marshals and Brigadiers in Florence.