Denise Bucumi-Nkurunziza (born 1 December 1969) is a Burundian ordained minister who was First Lady of Burundi from 2005 to 2020 as the wife of Pierre Nkurunziza.

[1] Bucumi-Nkurunziza was born in Gatsinda, Mwumba in Ngozi Province on 1 December 1969.

Bucumi-Nkurunziza became an ordained minister and was involved in charitable activities under her foundation Buntu as First Lady.

On the morning of 28 May 2020, she was airlifted to Nairobi, Kenya to be treated for COVID-19 during the COVID-19 pandemic in Burundi at Aga Khan University Hospital.

Although the cause of death was stated to be a heart attack, it was widely suspected that he had died of COVID-19.