[2] Pursuing this goal, she spent her summers working with architects, and from 1948 to 1952, after attending Kingsmead College,[3] studied in South Africa at the University of the Witwatersrand.

The couple spent the next three years working and traveling throughout Europe and part of their trip was to Italy with an itinerary devised by their friend, the architectural historian Robin Middleton with whom they had studied in South Africa and met up with again in London.

[10] In 1972, with Venturi and Steven Izenour, Scott Brown wrote Learning From Las Vegas: the Forgotten Symbolism of Architectural Form.

Scott Brown and Venturi strove for understanding the city in terms of social, economic and cultural perspectives, viewing it as a set of complex systems upon planning.

As part of their design process, the Venturi, Scott Brown & Associates firm studies the trends of an area, marking future expansions or congestions.

[14] For example, the Venturi, Scott Brown & Associates firm studied both the expansion of Dartmouth College campus along with the wilderness surrounding the perimeter of the area.

Guest rooms are typically made with Western taste, with fabrics, wallpaper, and carpet exclusively from the Venturi, Scott Brown & Associates firm that reflect the scenery outside.

By the beginning of the 1980s, critics characterized them as the most influential and visionary architects of the time and continued their path with a clear approach, with their radical theories of design.

[14] She has also served as principal-in-charge with Robert Venturi on the firm's larger architectural projects, including the Sainsbury Wing of London's National Gallery, the seat of the departmental council in Toulouse and the Nikko Hotel and Spa Resort in Japan.

[17] The prize organization, the Hyatt Foundation, stated that, in 1991, it honored only individual architects, a practice that changed in 2001 with the selection of Jacques Herzog and Pierre de Meuron.

"[21] In 1973, Denise Scott Brown wrote her essay "Learning From Pop", where she emphasized the importance of taking pop-culture into consideration when designing architecture.

Alongside Phyllis Lambert, Blanche Lemco van Ginkel and Cornelia Oberlander, she is one of four female architects profiled in the 2018 documentary film City Dreamers.