On Wednesday, September 16, 2009, Dennis K. Burke was sworn in as the United States Attorney for the District of Arizona.

He is a former Assistant United States Attorney for the District of Arizona prosecuting drug trafficking cases, was the Assistant Attorney General for Legislative Affairs at the United States Department of Justice, a Senior Policy Analyst for the White House Domestic Policy Council during the Clinton Administration and a Majority Counsel for the United States Senate Judiciary Committee, where he worked on three Supreme Court nominations, intellectual property as well as crime and law enforcement legislation.

Senator Dennis DeConcini (D-AZ) credited Burke and Rahm Emanuel with fostering and getting the 1994 Assault Weapon Ban passed.

On July 10, 2009, Burke was nominated by President Barack Obama to serve as the United States Attorney for the District of Arizona.

In 2013, Burke partnered with Noah Kroloff, Mark Sullivan, David Aguilar, John Kaites and Jerry Reinsdorf to found Global Security and Innovative Strategies.