In 2011, he received the prize for best player during the AEGON Future Cup in Amsterdam, a youth tournament in which teams like Ajax and Bayern Munich also competed.

[8] Praet debuted in Anderlecht's first team on 21 September 2011 starting in the Belgian Cup against Lommel United and provided two assists in a 4–0 win.

[12] On 16 September, he scored away to Galatasaray in the UEFA Champions League group stage to put Anderlecht in front, but the Turkish club equalised in added time.

[16] After being heavily linked with a move to reigning Serie A champions Juventus during the 2018 summer transfer window, in November 2018, Praet signed a contract extension with Sampdoria, extending his stay at the club until 2021.

[17] Praet was an ever present in the Sampdoria side during his three-year spell, appearing in 98 Serie A games and scoring four goals, as the club finished in the top half of the table all three seasons.

[9] On 8 August 2019, Praet signed for Premier League club Leicester City on a five-year contract, for a reported fee of €20 million.

[22] Praet returned to Leicester for the 2022–23 season, scoring his only goal of the Premier League campaign in a 4–2 away win over Aston Villa on 4 February 2023.

He made his senior international début coming on as a 76th-minute substitute for Christian Benteke after all four goals had been scored in the 3–1 friendly win over Iceland in Brussels.