Before the seat's creation in 1983 Reddish was part of the marginal Stockport North; the large Brinnington council estate (now in part bought under right to buy) was in the Labour safe seat of Stockport South; and Audenshaw and Denton formed the core of Manchester Gorton.

In the 2005 provisional recommendations of the Boundary Commission's Fifth Periodic Review, Reddish was to be repatriated with the Stockport constituency.

However, following a public inquiry into Greater Manchester's constituencies held in late 2005, changes to the original proposals for the county were made.

It was recommended that the Denton and Reddish seat should remain unchanged, with slight readjustments to reflect the new ward boundaries introduced in 2004.

Further to the completion of the 2023 Periodic Review of Westminster constituencies, the seat will be abolished for the 2024 general election, with its contents distributed three ways:[3]