The department is headed by the Secretary of State for Business and Trade, assisted by a number of junior ministers.

The ministers and senior civil servants from DIT were carried over to continue leading the new department.

The creation of the new department was described by Downing Street as an opportunity to provide "a single, coherent voice for business inside government, focused on growing the economy with better regulation, new trade deals abroad, and a renewed culture of enterprise at home".

[3][4] The department was responsible for finalising negotiations for the UK's to join the Comprehensive and Progressive Agreement for Trans-Pacific Partnership in April 2023, a free-trade agreement (FTA) between 11 countries around the Pacific Rim: Canada, Mexico, Peru, Chile, New Zealand, Australia, Brunei, Singapore, Malaysia, Vietnam and Japan.

The role is held concurrently with her position as Secretary of State for Business and Trade.