The Department of East Tennessee and West Virginia was a Confederate Army command in the Trans-Allegheny Theater during the American Civil War.

Commanders: Renamed on November 25, 1862 and extended to the border of eastern Kentucky.

On September 25, extended to include the areas of southwestern Virginia formerly encompassed by the Department of East Tennessee and forces east of Knoxville.

The Valley District was added on April 9, 1865 from the Department of Northern Virginia.

Commanders: Merged with the Department of Tennessee and Georgia on April 19, 1865.