The club plays their home games at Estadio Garcilaso, which they share with city rivals Cienciano and Cusco FC.

With a capacity of 45,056, the Estadio Garcilaso is the largest stadium in Cusco and has hosted numerous sporting events, most notably the 2004 Copa América which was held in Peru.

In 1970 Deportivo Garcilaso was invited by the Peruvian Football Association to participate in the Copa Presidente de la República.

In that phase they finished in third place, tied with Defensor Lima, behind ADT Tarma and Comercial Aguas Verdes de Zarumilla, and were eliminated from the tournament.

After being crowned champion of the Departmental League of Cusco for the fifth consecutive year, Deportivo Garcilaso arrived at the national phase with the conviction of having a good performance and winning the long-awaited title.

In the final of the 2022 Copa Perú they started by drawing 0-0 against Comerciantes, then won 3-0 against Defensor La Bocana, and against Atlético Bruces they thrashed 5-1 and by goal difference they obtained first place and were promoted to Liga 1 for the first time in their history.

The club debuted very well in the 2023 season, placing 7th on the aggregate table and qualified for the 2024 Copa Sudamericana, making their first international appearance.

The initial renovation was meant to add a roof and modern wall around the stadium as well, but was not implemented due to a low budget.

With a total attendance of 48,187 by the 10th matchday of the 2023 Liga 1, Deportivo Garcilaso ranked higher than notable clubs Sporting Cristal and FBC Melgar.

Upstart Real Garcilaso (now known as Cusco FC), founded in 2009, has outperformed Deportivo in recent years and now plays in the Peruvian Primera Division as well.