Derecske (Hungarian: Derecskei járás) is a district in central-eastern part of Hajdú-Bihar County.

The district is located in the Northern Great Plain Statistical Region.

The number of the inhabited places in Derecske District is 13.

Besides the Hungarian majority, the main minorities are the Roma (approx.

2,000 persons in Derecske District did not declare their ethnic group at the 2011 census.