Nyíradony (Hungarian: Nyíradonyi járás) is a district in north-eastern part of Hajdú-Bihar County.

Nyíradony is also the name of the town where the district seat is found.

The district is located in the Northern Great Plain Statistical Region.

Besides the Hungarian majority, the main minority is the Roma (approx.

1,000 persons in Nyíradony District did not declare their ethnic group at the 2011 census.