Dermorphin is a hepta-peptide first isolated from the skin of South American frogs belonging to the genus Phyllomedusa.

[2][3] Dermorphin is about 30–40 times more potent than morphine, but theoretically may be less likely to produce drug tolerance and addiction due to its high potency.

[5] Dermorphin appears to be made in these through an unusual posttranslational modification carried out by an amino acid isomerase.

[6] This unusual process is needed because the D-alanine in this peptide is not among the 20 amino acids coded for in the genetic code and thus the peptide cannot be synthesized in the usual way from the encodings in the genome of an organism.

Dermorphin has been illegally used in horse racing as a performance-enhancing drug.