Derwent is an unincorporated community in central Valley Township, Guernsey County, Ohio, United States.
Derwent lies in southeastern Ohio, a part of the Unglaciated Allegheny Plateau region.
State Route 313 (Clay Pike Road) runs on the southern edge of Derwent, and its interchange with Interstate 77 is a little over 1 mile (1.6 km) away.
The Penn Central rail line ran through the eastern portion of Derwent (heading south to Marietta) and which crossed the Baltimore and Ohio rail line ran immediately to the south, heading toward Cumberland, Ohio and which eventually terminated at the Muskingum Electric Railroad.
The former Penn Central line is in the process of being rebuilt by the Byesville Scenic Railway.