Descemer also performed in the United States in 1998 with the jazz ensemble Column B. Bueno studied music at Stanford University in Palo Alto California.
In 1999, after moving to New York, Bueno became a founding member of the Cuban latin fusion band Yerba Buena, writing or co-writing with the founder Andrés Levín from Venezuela many songs for their debut album President Alien.
The Batanga magazine wrote that, "The underground voice of AfroCuban fusion, Descemer Bueno, is now setting the pace for the future of Latin Music".
He wrote the song "Bailando" which appeared on Sex and Love and became an international hit credited to Iglesias featuring Bueno and Gente de Zona, and in some versions Sean Paul or others.
[13] Bueno also contributed to Quiero Guarachar, an album by Miami-based Afro-Cuban funk group PALO!, as a vocalist and co-composer of the song "Agua Pa' Los Santos", also featuring Pedrito Martinez and percussionist Roman Diaz.
[14] On January 18, 2019, Descemer Bueno released a music video for the song "Mátame" he recorded with Spanish singer Melody and El Micha.