[1] In 1939 his father, a German Jew from Berlin, fled to Bolivia with his family at the age of four to escape Nazi persecution.

[8] Drexler's song "Al Otro Lado del Río" appeared in the internationally acclaimed film The Motorcycle Diaries.

[10] After that, he released 12 Segundos de Oscuridad (2006); this album contained ten original songs and two covers: "High and Dry" from British band Radiohead and "Disneylandia" from Brazilian Titãs.

Juan Campodónico and Carlos Casacuberta, former members of rock band El Peyote Asesino, had produced Drexler's albums from Frontera to 12 Segundos De Oscuridad.

In 2008, he released a double live album, recorded in different concerts in Spain: Cara B (2008), mainly filled with songs previously unreleased.

Drexler recorded Amar la Trama (2010) on November 1–4, 2009 in Madrid, Spain in just four days, with musicians playing live on studio.

[13] Amar la Trama was recorded in a television studio in front of a small audience who were selected in an online contest.

One of the themes of this album is experiencing life, love, and the world in general with fresh eyes, a message that resonates most strongly in his hit song Cinturón Blanco.

For his work writing Spanish-language versions of singles by Colombian singer-songwriter Shakira, he has received five ASCAP Latin Awards.

[18][19][20] Drexler also received a Goya Award in 2010 with the song "Que El Soneto Nos Tome Por Sorpresa", written for the Spanish film Lope; the same year he was named Commander of the Order of Isabella the Catholic for his musical contributions.