Francesco Cennini de' Salamandri (21 November 1566 – 2 October 1645) was an Italian Catholic Cardinal.

Cennini de' Salamandri was born 21 November 1566 in Sarteano into a noble family of Marquises of Castiglioncello del Trinoro.

He was named the parish priest of Sarteano, and Archpriest and Vicar-General of the Diocese of Chiusi before going to Rome to work as a legal advocate.

In 1612, he was elected the Bishop of Amelia and became a Signatory of the Apostolic Penitentiary and served as Governor of Rome for eight years.

He was appointed the Cardinal-Priest of Sabina-Poggio Mirteto in 1641, resigned as Bishop of Faenza in 1643 and participated in the Papal conclave of 1644 that elected Pope Innocent X.