[2] Debbie Millman has interviewed over 250 guests[1] including Amanda Palmer, Chris Ware, Malcolm Gladwell, Massimo Vignelli, Steven Heller, Marian Bantjes, Tina Roth Eisenberg, Alain de Botton, Alison Bechdel, and Stefan Sagmeister.

[5][6] The podcast has also been on top of the charts by a number mainstream media publications, such as Business Insider,[7] HGTV,[8] Architectural Digest.

[9] Design Matters is hosted by Debbie Millman and features personable, in-depth conversational interviews with "industry-leading graphic designers, educators, authors, change agents and thinkers".

[10] Episodes are published approximately 30 times a year and generally range in length from 25 to 60 minutes.

In September 2020, it was announced that Design Matters would be joining the TED podcast family.