Sayle partnering with Special Olympics during high school and later helping low income women develop skills to enter the workforce.

She worked as Chief Clerk of the United States Senate Select Committee on Intelligence, as a Director of Operations for the Senate Republican Conference, Chairman John Thune, as an assistant to congressman Joe Barton of Texas, and worked as an aide in President George H. W. Bush's White House until 1992.

For several years, she was correspondence director for America's Promise Alliance, the nonprofit organization founded and led by retired general Colin L. Powell, USA (Ret).

She continued in that role until late 2004, when she was appointed Deputy Assistant to the President and Director of the USA Freedom Corps.

[1] The USA Freedom Corps was a fifth policy council within the Executive Office of the President during the Bush administration, tasked with strengthening the culture of service, civic participation, and volunteerism among the American population.