Tan first came to prominence in the entertainment industry when he finished runner-up to Andie Chen in Star Search 2007.

He was awarded a contract with Mediacorp and began his part time acting career with some minor roles in various Channel 8 dramas.

Desmond Tan was educated at Pioneer Secondary School and Jurong Junior College.

[6][7] He completed his national service in the 1st Commando Battalion (1 CDO BN) with the rank of Captain.

[9] On 4 October 2023, Tan announced on social media that his wife was pregnant with a baby girl.