Desouk dates back to at least c. 3200 BC and was part of the ancient city of Buto before the unification of Upper and Lower Egypt.

Other proposal derives it from the rare Arabic verb dasaqa "to overflow (about a basin)" and its nominal form daysaq "bassin full of water" [5] which in turn has its origin in Ancient Greek: δίσκος, lit.

The mosque is the final resting place of the last Sufi pole, Imam Ibrahim El Desouki, established around the year 1277.

In Desouk, an annual celebration is held for the birth of Ibrahim El-Desouki in October, lasting a week with strict security measures.

[13] Among the festivities, the custodian of the Ibrahim El-Desouki shrine rides a horse and is paraded through the streets of Desouk after the afternoon prayer on the final day of the celebration.

This was done for worship and to draw closer to the goddess Wadjet, the Lady of the City, a central figure in the Egyptian myth of Isis and Osiris.