It is the newest installment in the Desperados series since the 2007 spin-off title Helldorado, and it was released for Microsoft Windows, PlayStation 4, Xbox One, Linux, and macOS.

[1][2] Desperados III is a real-time tactics stealth video game, where players need to clear specific objectives while navigating through the vast maps.

[4] To add an extra layer of strategy, players can utilize the "showdown mode" to temporarily pause the game and coordinate chained actions of the squad.

It borrows several elements from the Spaghetti Western movie Once Upon a Time in the West, including the main villain's name "Frank", a railway company tycoon as a secondary enemy, and the fictional town Flagstone as one of its mission settings.

In addition to John Cooper, the game also includes Hector Mendoza, Doc McCoy, Isabelle Moreau, and Kate O'Hara as playable characters.

In the meantime, the mayor's prospective bride, Kate O'Hara, finds out that her betrothed has sold her family's ranch to Vincent DeVitt, a wealthy tycoon.

The newly met pair promptly escape the mansion and head for the O'Hara ranch to defend it from the attacking DeVitt's company men.

Combining all the map pieces, the group discovered that Magnus put the gold in the old fortress called "The Eagle's Nest" which is now occupied by Frank's former henchmen.

[7] Since the last game in the series was released more than a decade ago, the team made Desperados III a prequel story so that it can be accessible to new players who are new to the franchise or new to the genre.

[11][12] Beginning in July 2020, Mimimi and THQ Nordic started supplying free updates for the game, which include additional mission scenarios.

[13][14] Between September and November, Mimimi and THQ Nordic also began publishing a purchasable three-part DLC story expansion, titled "Money for the Vultures".

The plot is set three months after the events in the main game; Rosie, an NPC previously met in Baton Rouge (Mission 7), hires Cooper's group to hunt for the hidden wealth of Vincent DeVitt.

[25] GameSpot praised the save system, writing that it gave the player freedom to take risks without consequence, "What's remarkable is that this quick-save and quick-load routine never becomes frustrating.

[29] While liking the showdown system, PC Gamer criticized the visuals as being mostly uninteresting, "Though they're impressive stealth sandboxes, none of the maps are lookers.

[27] Rock Paper Shotgun praised the character of Isabelle Moreau, feeling she was a standout from the cast, "Nicely voiced by Debra Wilson, and possessing two voodoo-inspired abilities that are refreshingly different and a hoot to use, the sickle-wielding Creole sorceress is a lovely addition to the canon.