[citation needed] Its uniform colors between 2014 and 2016 featured blue clothing with yellow sleeves and socks.

Guadalupe is the only club from Lobata to get a regional and a national competitive honor.

The club advanced into the 2012 São Tomé and Príncipe Cup and faced Sporting Clube do Príncipe and lost 2–1, as Sporting Príncipe was the national winner, Guadalupe was the first ever São Tomean club to enter the CAF Confederation Cup,[2] the club faced US Bitam of Gabon and scored nothing and lost 0–5, Guadalupe scored only a goal in the second leg and their results were awful, Desportivo Guadalupe faced a huge defeat, lost 1–12 to Bitam, one of the largest in history and the largest to a São Tomean team.

In cup title possession rankings, it was shared with Sporting Praia Cruz in 1982, later Vitória Reboque in 1984.

Along with a few other clubs, Guadalupe's total became second in 1985, third in 1993 behind Sporting Praia Cruz, fourth behind GD Os Operários of Príncipe in 2003, fifth in 2010 and sixth since 2016.