Written and illustrated by Keitaro Takahashi, Destro 246 was serialized in Shogakukan's seinen manga magazine Monthly Sunday Gene-X from April 19, 2012,[2][3] to April 19, 2016.

[4][5] Shogakukan collected its chapters in seven tankōbon volumes, released from October 19, 2012,[6] to June 17, 2016.

[7] A spin-off novel written by Kosuke Fujiwara, titled Destro 246 Hammer Rage (デストロ246 ハンマーレイジ, Desutoro 246 Hanmā Reiji), was published on February 19, 2019 (with a preview chapter published in Monthly Sunday Gene-X on January 19 of the same year).

[8][9] A prequel manga, titled Destro 016 (デストロ016, Desutoro 016), started in Monthly Sunday Gene-X on April 19, 2021.

[13] The seven volumes of Destro 246 debuted on Oricon's weekly chart of best-selling manga.