[1] In a review of "Detroit vs. Everybody" for Rolling Stone, writer Kory Grow outlined that the song features "Several generations of the Motor City's most vital rhymers [revisiting] the struggle they rose above to break out of their hometown while still defending it", with lead artist Eminem reminiscing about his "pre-megastar days".

Kory Grow of Rolling Stone awarded the single three out of five stars, describing the song as "an appropriately reflective coda" for Shady XV and praising the performances in particular of Eminem and Big Sean, the latter of whose verse he claimed "hits hardest".

[2] Complex writer Zach Frydenlund praised the track, claiming that it was "the most anticipated song" to be featured on Shady XV.

[8] It was described as "a star-studded, gorgeous black-and-white music video" by Spin magazine's James Grebey, who detailed that "The footage is crisp and austere, giving the assembled talent lots of room to play around and show off their considerable skills and admiration for their hometown".

[4] The video was filmed in various locations in Detroit, including Ford Field, Henry the Hatter and Comerica Park; it features Royce and Loaf performing "on rooftops", and Brown and Sean "in a pair of dilapidated buildings".