Out of the mare Kelli's Ransom, Devil May Care was sired by Malibu Moon, a son of the multiple Grade I winner, A.P.

She was owned by Glencrest Farms and trained by Todd Pletcher Devil May Care won the Grade I Frizette Stakes at two.

Devil May Care was the only filly entered in the 2010 Kentucky Derby, going off at odds of 10:1.

The daughter of Malibu Moon returned on June 26, 2010, to win the Mother Goose Stakes in fine style, covering the 1 1/16 distance in a record time of 1:42.06.

Devil May Care was euthanized on May 4, 2011 after a confirmed diagnosis of lymphosarcoma, a form of cancer.