[4] Booker was born and raised in Grand Rapids, living with his mother, who is of Mexican descent[1][5] while his African-American father pursued a professional basketball career internationally.

[12] In December, he hit a buzzer beater from just beyond half court to beat Harrison Central High School, improving Moss Point's record to 4–6 on the year.

[4] At that time, his father told reporters that Booker was drawing interest from Mississippi State, Ole Miss, Florida, Alabama, Georgetown, Michigan and Missouri.

[4] Booker was limited to just 14 points, with no field goals made in the second half, in a 57–55 win over Gautier High School in the opening round of the Division 7-5A tournament.

[17] Wayne County focused their defense on Booker, holding him to a single, first-quarter free throw, en route to a 57–37 victory that ended Moss Point's season.

[15] In an early December game, Booker outscored the entire Ocean Springs High School team 40–39 through three quarters en route to a 48-point finish as Moss Point won 100–55.

[22] The following week, Booker left a game against Harrison Central High School in the third quarter with a sprained MCL; he had scored just 9 points, but grabbed 7 rebounds.

[28] Booker, who struggled with his outside shot due to a wrap on his injured right wrist, hit all 17 of his free throws en route to a game-high 30 points in the win.

[40] He took an official visit to the University of Kentucky on the weekend of September 9 to watch an alumni exhibition game; fellow 2014 prospects Jahlil Okafor and Tyler Ulis also attended.

[43] At an October 31 ceremony at his high school gymnasium, Booker announced he had chosen Kentucky, citing the program's history and his affinity for coach John Calipari as primary factors in his decision.

[54] Booker joined future Kentucky teammates Ulis and Lyles on the West team in the 2014 McDonald's All-American Game, while Towns suited up for the East.

[58] Sources: In Kentucky's first exhibition game against the University of Pikeville on November 2, 2014, Booker was the team's second leading scorer with 16 points on 6-of-9 shooting, including two three-pointers; he also had three assists.

[61] In Kentucky's next game against Texas-Arlington, Booker set a new season high with a team-high 19 points on 7-of-8 shooting, including five made three-pointers, in a 92–44 win.

[85][86] With teammate Eric Bledsoe returning from injury in 2016–17, Booker was retained as the starting shooting guard while Brandon Knight was moved to the bench.

[90] He had a second straight 39-point effort in a two days later[91] to become the youngest player in NBA history to record consecutive games of 39 or more points in the regular season.

[106] On February 17, Booker won the Three-Point Contest over Klay Thompson and Tobias Harris in the final round after setting a new record with 28 points.

[116][117] On January 24, Booker became the fifth-youngest player in NBA history to reach 5,000 career points, behind LeBron James, Kevin Durant, Carmelo Anthony, and Dwight Howard.

[126] In addition, his streak from December 28 until January 7 made him the only player since the 1983–84 NBA season to record six straight performances of 30-plus points and 6-plus assists with 47% shooting efficiency.

On August 4, Booker hit a fade-away game-winning jumper at the buzzer over Paul George and Kawhi Leonard to lift the Suns to a 117–115 win over the Los Angeles Clippers and bring their record there to 3–0 at the time.

[132][133] He returned to action on February 1, reaching 700 career three-point shots, including a game-winning 3-pointer with 1.5 seconds left in the game, to win 109–108 over the Dallas Mavericks.

[142] On May 23, Booker would make his NBA playoff debut, posting 34 points, 7 rebounds and 8 assists in a 99–90 victory in Game 1 of the First Round over the defending champion Los Angeles Lakers.

[143] On June 3, Booker recorded a playoff career-high 47 points, along with 11 rebounds to lead the Suns to a 113–100 series-clinching victory over the Lakers in Game 6 to advance to the Conference Semifinals against the Denver Nuggets.

[145] In Game 1 of the Conference Finals, Booker recorded his first career triple-double with 40 points, 13 rebounds, and 11 assists, in a 120–114 win over the Los Angeles Clippers.

[160] On July 7, 2022, Booker agreed to a four-year, $224 million maximum contract extension with the Suns;[161] the same day, he was announced as one of the cover stars of NBA 2K23.

[166] He became the sixth-youngest player to reach 12,000 career points trailing only LeBron James, Kevin Durant, Kobe Bryant, Carmelo Anthony, and Tracy McGrady.

[173][174] In Game 5 of the Suns’ first round playoff series against the Los Angeles Clippers, Booker put up 47 points, 10 assists, and eight rebounds in a 136–130 win.

[175][176] In Game 3 of the Western Conference Semifinals, Booker tied a playoff career-high 47 points and put up six rebounds, nine assists and three steals in a 121–114 win against the Denver Nuggets.

[187] After another 44-point outing against the Orlando Magic on January 28, Booker was named the Western Conference Player of the Week for the ninth time in his career, averaging 42 points, five rebounds, and 63.9% from the field in four games.

[198] He played a crucial role on Team USA leading up to their gold medal win on August 10, with head coach Steve Kerr calling Booker their "unsung MVP" throughout their run.

In 2020, Booker was named a global ambassador to the Special Olympics for his support for his younger half-sister who has microdeletion syndrome, a genetic chromosomal disorder.