[2] In January 2022, DeFrancesco won the 60th running of the Daytona 24, alongside his teammates Eric Lux, Patricio O'Ward and Colton Herta, in the LMP2 class.

[6][7][8] In 2014, he sustained an injury to his wrist that required two surgeries and that kept him out of a full racing series for roughly year.

As part of his rehabilitation, Devlin attended the Carlin Academy, where he used a combination of simulators and on-track testing to prepare for FIA Formula 4-style racing.

[1] DeFrancesco joined Carlin Motorsports for the 2016 MSA Formula season,[9][7] taking three wins and finishing 5th in the points standings.

[20] He was forced to withdraw from the following round to undergo dental surgery,[21] and subsequently made the switch to join GP3 Series for the remainder of the 2018 season, teaming up with MP Motorsport.

In February 2020, it was announced that Devlin would rejoin Trident Racing for a second year in the championship,[26] but he was forced to withdraw from the season amongst fears of COVID-19, DeFrancesco being immunocompromised.

DeFrancesco joined the IndyCar Series for the 2022 season, driving the Number 29 car entered as Andretti Steinbrenner Autosport.

DeFranseco will return to the IndyCar series in 2025 after signing a multi-year deal to drive for Rahal Letterman Lanigan Racing.