The player has twelve in-game hours to capture Turkey Monkey, "an insane, horrible freak mutant, the result of a rogue recombinant DNA experiment",[1] and find the cure for osso bucco myelitis, a bone-dissolving disease that forces its victims to walk around in skeleton-like suits.

Devo's founders Gerald V. Casale and Mark Mothersbaugh co-wrote the story to the game.

Ty Burr from Entertainment Weekly considered the game to be "a major disappointment on all counts", citing its visuals, gameplay, and buggy navigational controls.

"To think of the trees felled for this game's packaging, the miles of videotape run through, lines of dialog written and hopelessly rewritten, code keyed in and compiled and recompiled, marketing hype worked up and spun out, and raw energy wasted in producing the however many thousands of CDs Inscape agreed to permanently burn this trash into, one can only walk away feeling pity for all of the resources, human or otherwise, that were inexorably drawn into the band's distressing foray into computer gaming.

[8] Conversely, Ralph Lombreglia of The Atlantic praised the game, calling it "wonderfully well-conceived and well-written", and "one of the best pieces of interactive multimedia I've ever seen, period.