The story follows superhuman Meriem Cooper, a 19-year-old jungle woman who battles dinosaurs and other prehistoric creatures in the Cretaceous period.

Root credits the artist William Stout, as well as the Playboy cartoon feature Little Annie Fanny, as his inspirations for the character.

The artists Devon Massey and Robert Durham have done much of the cover art for the series and related one-shots and spin-offs.

Regarding the character's creation, Root commented: Cavewoman was inspired by Little Annie Fanny and William Stout.

She's got a body with kind of a Little Annie Fannie face with Danni Ashe's boobs and Nina Hartley's butt".

After the events of Cavewoman: Rain the town of Marshville was destroyed, and Meriem and the inhabitants migrated to the shores of the Pangaean Sea.

The first comic Cavewoman: Pangaean Sea Prologue was first published in 1999, and the series lasted eleven issues from 2000 to 2009.

After Robert died of unknown causes, Gail turned to drugs, which led her to fall in with an unsavory secret group of government agents.

After first being thwarted, Gramp made a mysteriously superhuman return, defeating the agents easily and taking 8-year-old Meriem away on a hovercycle from the future.

Thus, the trio began an ongoing adventure through time while on the run from dinosaurs and a secret branch of the government.

After more than ten years, and growing into a buxom, voluptuous 19-year-old, Meriem lived in the local jungles naked, savage, happy, and free.

Not wanting to be naked and savage anymore, she eventually made a jungle bikini (with dinosaur teeth hanging on the strings) out of a leopard-printed snakeskin blanket.

A high-caliber gunshot to the back[7] and bites from Velociraptors have failed to penetrate her tough skin.

Things that have been proven able to penetrate her skin, or otherwise injure her, are attacks that are directed with great strength or force, such as a Tyrannosaurus bite, Klyde's blows, or armor-piercing ammunition.

The worst injury Meriem is shown taking is when she battled a berserk Klyde during Cavewoman: Rain.

She remains in this "death state" while her enhanced molecular structure slowly repairs itself, without Meriem being able to eat anything to hasten the healing process.

The citizens of Marshville bury her, thinking she is truly dead, though the healing effect repairs the damage after two weeks.