[3] He attended The Theatre School at DePaul University but was cut after his first year and changed his major to film and animation, where he was introduced to The Second City by his best friend and writing partner Aasia Lashay Bullock.
[3] They were hired there after a producer saw his and Bullock's original show Uncle Tom & Jerry Curl: A Black History Month Experience.
In 2016, he wrote and performed Black Side of the Moon at Woolly Mammoth Theater in D.C.[5] He left Second City in 2017 to pursue stand-up.
[6] In April 2018, 3Peat's sketch The Blackening was released online on Comedy Central, about "an all-Black group of friends (who ain't got no business camping) as they get chased by a serial killer.
[2] Directed by Tim Story and starring Perkins, Antoinette Robertson, Jermaine Fowler, Yvonne Orji, and Jay Pharoah, the film wrapped production in December 2021.
[12] Perkins will write and executive produce the workplace sitcom Chopped & Screwed for ABC in collaboration with Phoebe Robinson.
[14] The show is a multi-camera sitcom centered on a Black barbershop and beauty salon that must come together as one entity to serve the superficial and therapeutic needs of their customers and community.
[14] In 2022 it was announced that Perkins will executive produce and write Clue, an animated television series adaptation based on the 1985 film.