Raised Catholic, Orji is now a devout Protestant and has stated that she will remain a virgin until marriage.

However, she was inspired to do comedy as a graduate student when she performed stand-up in the talent portion of a beauty pageant.

[9] She also hosted the romantic comedy reality dating series My Mom, Your Dad, which premiered on HBO Max in 2022, which ran for a single season.

In 2008 and 2009 she spent six months working in post-conflict Liberia, with Population Services International (PSI), an NGO that utilizes social marketing in the adoption of healthy behaviors.

She currently lends her time and voice as a (RED) Ambassador, a Literacy Champion for Jumpstart, and working with JetBlue for Good.