Bryan Keith "Dexter" Holland (born December 29, 1965) is an American musician, best known as the co-founder, lead vocalist, rhythm guitarist, main songwriter and composer, and only constant member of the punk rock band the Offspring.

[5][6][7] He suspended his studies to focus on music when the Offspring found success in 1994,[3][8] but later resumed and earned a PhD in molecular biology in May 2017.

[7][9] He defended his thesis, "Discovery of mature microRNA sequences within the protein-coding regions of global HIV-1 genomes: predictions of novel mechanisms for viral infection and pathogenicity", under doctoral advisors Suraiya Rasheed and Bob Baker.

[3] Holland was a doctoral student at the Laboratory of Viral Oncology and Proteomics Research, Keck School of Medicine, where he was supervised by Professor Suraiya Rasheed.

[21] The original academic paper describes the use of computational molecular biological (in silico) approaches to identify microRNA-like sequences in HIV.

These sequences are suggested to have evolved to self-regulate survival of the virus in the host by evading its immune responses and thus influence the persistence, replication, and pathogenicity of HIV.

[22][24] The label depicts Holland with bandoliers, revolvers, a sombrero and shades, a design that OC Weekly magazine described as parodying the logo for Tapatío hot sauce or Pancho Villa.

[25] Holland, who grew up in Southern California where Mexican cuisine is considered a "part of the way of life", wondered "if [he] could do [a hot sauce] better".

[26] On the conception of the hot sauce, Holland states that in the early 2000s, while eating Mexican food, he began to read the label of a bottle of Tapatío; "It just clicked that I had to make one.

[25] In 1997, Holland and former Dead Kennedys singer Jello Biafra teamed up to form the FSU Foundation, which raised funds through charity concerts.

[28] Holland's early musical influences include Aerosmith, the Beatles, the Sex Pistols, the Ramones, KISS, Bob Marley, Queen, and the Rolling Stones.

[29] All of Holland's Ibanez RG body guitars are made out of mahogany and fitted with DiMarzio Super Distortion bridge pickups.