Diamond Creek Road provides the only vehicular access to the Colorado River between Lees Ferry, 225 miles (362 km) upriver and Pierce Ferry, 52 miles (84 km) downriver.

Rafting trips also launch from the same location and proceed downriver to Lake Mead.

The Hualapai tribal government charges a fee for all vehicles and people traversing the road.

[3] During periods of heavy rain Diamond Creek is prone to flash flooding.

Flash floods have historically damaged or destroyed the Diamond Creek Road forcing closure and, in one instance, washing vehicles into the Colorado River.