Her work emerged from the 1960s renaissance of interest in fiber art.

While studying at the University of Pittsburgh, she met her future husband, artist William Itter, who encouraged her to experiment with hand-tied knots.

[3] Itter used fine threads, small knots, and bright colors, whereas most fiber artists working at the time were producing large sculptural works from undyed fibers tied into large knots.

[4][5] Itter was inspired by historical textiles from Peru, Japan, and Africa.

[6] Itter had limited herself to brightly dyed thread and a single type of knot by 1974.