She is best known for her character DiDi Glitz, who addresses transgressive social issues such as feminism, female masturbation, body image, and miscarriages.

[7] Kominsky and Noomin put together a 36-page one-shot issue of Twisted Sisters in 1976, published by Last Gasp, which featured their own humorous and "self-deprecating"[8] stories and art.

In 1978, Noomin edited the Print Mint one-shot Lemme Outa Here, a comics collection of stories of life in mid-century American suburbs, featuring Noomin, Michael McMillan, Robert Armstrong, Griffith, Robert Crumb, Aline Kominsky, Kim Deitch, Justin Green, Mark Beyer, and M. K. Brown.

In 1980, Noomin collaborated with Les Nickelettes, a San Francisco-based women's theater group, to produce a musical comedy based on DiDi Glitz.

A cabaret version of the show, titled Anarchy in High Heels, was later performed at New York City's Westbeth Artists Community.

[9] In 1991, Noomin edited and put together a 260-page trade paperback anthology which she called Twisted Sisters: A Collection of Bad Girl Art (Viking Penguin), featuring the work of herself, Kominsky-Crumb, and 13 other female cartoonists, including many former Wimmen's Comix contributors.

[8] The success of that book led to Kitchen Sink Press publishing a four-issue Twisted Sisters Comix limited series in 1994, also edited by Noomin, with each issue featuring 44 pages of new comics by a number of female contributors.