[4] Diane's father treated her well: her household included a governess, tutors, maids of honor, chamber valets, and even a tailor.

[7] On 13 February 1552, when Diane de France was thirteen, a contract was signed by which she married Orazio Farnese, Duke of Castro (French: Horace Farnèse).

[8][9] The wedding ceremony on 15 February 1553 was attended by Orazio's brother Cardinal Alessandro Farnese and included masquerades and carnival banquets.

The annual revenues of about 6,000 livres were meant to compensate for the gift of 50,000 écus promised for her first marriage but never paid from the royal treasury.

[4] Diane was widowed for a second time in 1579, after helping make her husband a leader of the politiques, a moderate Roman Catholic group in France.

[14][15] Diane also enjoyed much respect at the court of Henry IV, King of France, and superintended the education of his son Louis XIII.