[5] She has collaborations with other YouTube personalities, including fellow science communicator Derek Muller of the channel Veritasium, maker Simone Giertz, and mathematics animator Grant Sanderson of 3Blue1Brown.

[11] Cowern began as outreach coordinator at University of California at San Diego's Center for Astrophysics and Space Sciences research unit.

[1] She started making science videos while working as a mobile app developer at General Electric.

[22] On June 23, 2022, she announced she would be producing a science-based talk show for Curiosity Stream's Originals called Proof of Concept.

[24] In 2014, she won the top video prize from the Alan Alda Center for Communicating Science at Stony Brook University.

She was hospitalized in March 2023, as her symptoms similar to myalgic encephalomyelitis/chronic fatigue syndrome continued to worsen, leaving her unable to move.

[33][34][35] However, on November 20, 2024, Cowern made an update to her channel indicating that while she "still can't get out of bed," she had been improving in her ability to perform certain activities and, "getting back [her] brain.