[5] Following high school in Armada, Enberg attended Central Michigan University, where he played college baseball and earned a bachelor's degree in 1957.

He also hosted the syndicated television game show Sports Challenge and co-produced the Emmy Award-winning sports-history series The Way It Was for PBS.

For the next 25 years, he broadcast a plethora of sports and events for NBC, including the National Football League, Major League Baseball, the National Basketball Association, the U.S. Open golf championship, college football, college basketball, the Wimbledon and French Open tennis tournaments, heavyweight boxing, Breeders' Cup and other horse racing events, and the Olympic Games.

Enberg replaced Curt Gowdy as lead play-by-play announcer for the NFL on NBC in 1979, and on the network's telecast of the Rose Bowl in January 1980.

According to his autobiography, Oh My!,[12] Enberg was informed by NBC that he would become the lead play-by-play voice of Major League Baseball Game of the Week beginning with the 1982 World Series (for which he served as pregame host and shared play-by-play duties with Joe Garagiola alongside analyst Tony Kubek) and through subsequent regular seasons.

Enberg added that NBC also gave him a significant pay increase as a pseudo-apology for not coming through on the promise to make him the lead baseball play-by-play man.

Enberg returned to the Angels' radio booth to call 40 games in 1985, citing a desire to reconnect with the sport, which he has described as having been "in my DNA since I was in diapers".

Enberg was also in Toronto[14] to do the pregame for Games 1 and 7 of the 1985 American League Championship Series alongside Rick Dempsey[15] (who was still active with Baltimore at the time).

NBC planned to use Enberg as one of its announcers for The Baseball Network coverage in 1994,[16][17] but the players' strike that year ended the season before he had the opportunity to call any games.

Enberg during his tenure at CBS, was notably on the call[18] alongside Dan Dierdorf for an NFL game between the New England Patriots and New York Jets on September 23, 2001.

Bledsoe's injury resulted in Tom Brady becoming New England's quarterback, beginning the Brady–Belichick era for the Patriots that saw them enjoy nearly two decades of dominance and win six Super Bowl titles.

Another enduring element of Enberg's broadcasting legacy was his ability to provide warm and poignant reflections on the sporting events he covered.

Enberg returned to call one match and serve as an essayist during the 2014 US Open, to help commemorate CBS's last year covering the event before ESPN took over in 2015.

[23] On September 14, 2009, Juan Martín del Potro defeated Roger Federer to win the Men's US Open Championship.

Enberg declined the request saying that he was running out of time but went on to list the corporate sponsored prizes del Potro won.

[24] A couple of minutes later, Del Potro made the same request again and only then Enberg relented saying "Very quickly, in Spanish, he wants to say hello to his friends here and in Argentina".

[24] A CBS executive later defended Enberg, noting that the contract with the United States Tennis Association required that certain sponsors receive time during the ceremony.

[26] In December 2009, Enberg was hired as a television play-by-play announcer by the San Diego Padres, signing a multi-year deal to call 110–120 games a season for channel 4SD.

[29] In 2012, Enberg returned as play-by-play voice of the Padres as they moved their telecasts from 4SD to Fox Sports San Diego, in the first year of a 20-year deal between the team and the newly formed network.

In his last week on air, he made a guest appearance with Los Angeles Dodgers announcer Vin Scully, who also was retiring at the end of the baseball season, after a 67-year career.

For Fox Sports Net, he called his final college basketball game on November 11, 2012, aboard the USS Midway alongside Steve Kerr.

(1970), the film Rollerball (1975), and the American-dubbed version of the animated UK Christmas special Robbie the Reindeer: Hooves of Fire (2002); made appearances in the films Two-Minute Warning (1976), Gus (1976), Heaven Can Wait (1978), The Longshot (1986), The Naked Gun (1988), and Mr. 3000 (2004); and appeared as himself in episodes of such television programs as The King of Queens and CSI: NY.

In addition, Enberg was seen in a series of commercials for GTE during the 1980s and early 1990s, and was the voice of the announcer in the classic Talking Football tabletop game from Mattel.

A hallway in the Macomb Academy of Arts and Sciences, which is run by Armada school district and shares the building with its administration office, was named after him.

In 1997, the College Sports Information Directors of America (CoSIDA) honored Enberg with an award in recognition of his longtime support of the organization's Academic All-America program.

Enberg continued to be an avid supporter of the program, often lending his voice to video presentations related to CoSIDA's annual Academic All-America Hall of Fame ceremony.

[40] Enberg was the second American sportscaster (after Curt Gowdy) to be selected for broadcasting awards from each of the Halls of Fame in professional football, basketball and baseball.

At the time of his death, he was married to his second wife, Barbara (née Almori), with whom he had one son, Ted Enberg (also a sportscaster), and two daughters, Nicole and Emily.

Those attending the April 1 matinée included Hall of Famers coach Dean Smith (whom McGuire defeated in the 1977 NCAA Championship in Atlanta) and former UCLA All-American center Bill Walton.

It has since been booked in San Diego, Los Angeles, Las Vegas, Chicago, Portland, Maine, North Carolina and Indiana.