In 1532, ambitioning freedom from Atahualpa's brutal rule and revenge for his attacks, Vilchumaly and other notables to receive and ally with Pizarro, whom he had notice of from his previous voyage to the Inca Empire in 1526.
[2] Pizarro initiated his journey to the core of Inca Empire with the Cañaris to his side, concluding in capture of Atahualpa in Cajamarca, where Vilchumlay was probably present.
[2] Diego Vilchumlay served in the Hispanic side during the conquest of the territories still held by former general of Atahualpa, like Lita and Quilca [es], and had an outstanding role during the revolt of Manco Inca.
Manco's lieutenant Quizu Yupanqui besieged Lima in August 1536, to which Diego de Sandoval and Vilchumlay answered gathering a Cañari relief army.
He was rewarded for his service with the territories of El Pan, Toctesí and Hazmal, and his name is recorded in the foundation of Cuenca, in the ancient Cañari center of Tomebamba and close to his own domains.