[citation needed] Diepoxybutane is used as a chemical intermediate, as a cross-linking agent for polymers and textiles, and as a preservative.

[5] Diepoxybutane irritates the nose, throat and lungs, causing coughing and shortness of breath.

Longer exposure periods can cause pulmonary edema, and damage to the liver and kidneys.

[6] It is experimentally shown that diepoxybutane can cause tumors in rodent species at several different tissue sites and by several different exposure routes.

[quantify] Injection of diepoxybutane into mice and rats caused lung tumors.