[7] He was the Chairman of the Twenty Point Programme and held additional charges of the Ministries of Panchayati raj, Law, Agriculture and Social justice in the Government of Rajasthan.

[2][4] Shortly after obtaining a degree in surgery and medicine, Singh began experiencing symptoms of muscle weakness and regular fatigue, and was hospitalised in AIIMS for a stroke.

[10][page needed] Singh joined the state government's Department of Medicine[4] as an obstetrician in 1977, initially in Nagar tehsil and later Kumher in Bharatpur, Rajasthan.

[4] During Singh's tenure, there were multiple government poverty relief schemes and programmes in Rajasthan, such as free testing for dengue to help control the disease.

[13] In 2007,[14] Singh introduced a programme to improve government health facilities and opened services centres at the panchayat level with the intention of making it more accessible to the poor.

[15] In 2008, along with Norway's Prime Minister Jens Stoltenberg,[16] Singh launched the Rajasthan-Norway joint health programme, which aimed to eradicate polio and modernise existing facilities and infrastructure.

Singh would monthly review data on criminal cases being reported in hospitals and government medical facilities in the state.

The agitation almost paralysed government machinery in Eastern Rajasthan and propelled Chief Minister Vasundhara Raje to take drastic measures to ensure law and order prevailed.

Amidst heightened tension, Chief Minister Raje assigned the responsibility to mediate with agitators to her cabinet colleague, Dr. Digamber Singh.

[2][4][23] Under his leadership, numerous multi-dynamic urban and residential projects were implemented within the state[24] and the FDI level rose by 9% as multiple special economic zones were introduced.

[27][28] The Rajasthan Government, under Singh, initiated ‘FIESTA’ events at engineering institutions in a bid to engage rural talent and open collaborative opportunities abroad.

The opposition further termed Singh's appointment as unconstitutional, as it surpassed the authority of elected members, serving as Cabinet Minister.

Intellectuals and policy makers too expressed confidence in Singh's appointment, knowing his acumen and abilities, plus the two decade long experience in government functioning.

[8] While campaigning in the 2015 Delhi Legislative Assembly election, Singh began complaining of back pain and shortly after was diagnosed with pancreatic cancer.

[41] He received initial treatment and underwent surgery at the Memorial Sloan Kettering Cancer Center in New York City, USA.

Dr. Digamber Singh was also appointed in-charge for the upcoming 2017 Uttar Pradesh Legislative Assembly election and campaigned for the party in the region.

Singh gave his last interview on 7 October with News 18 journalist Shripal Shekhawat and ten days later went to a Diwali celebration in Kumher, where he held his final press conference.

He was rushed to the Eternal Heart Care Centre in Jaipur the next day[2][41] after complaining of chest pain[4] and was admitted for swine flu.

[44] Dr. Digamber Singh's death, 14 months prior to the 2018 Rajasthan Legislative Assembly election, came as a big blow to the Bharatiya Janata Party.

Singh, a mass leader, had a sway among the Jat Community and voters in Eastern Rajasthan, the void of which was evident in the assembly election the following year.

On 17 December 2019, he was appointed, President of Bharatiya Janata Party Bharatpur, a post held by his father in his early political career.