[7][8] Despite not having played Super Rugby, Ioane was selected for the Wallabies squad to tour France and the United Kingdom under coach Eddie Jones at the end of 2005.

[6] Ioane spent the latter part of the 2007 season playing for his previous hometown Melbourne Rebels in the Australian Rugby Championship.

[14] Unfortunately his season was disrupted by a broken hand and two periods of suspension for careless tackles, but his talent still earned him a place in the Wallaby squad and game time with Australia A in the IRB Pacific Nations Cup.

In 2009, Ioane was switched to outside centre to cover an injury and proved a sensation, making the position his own until a shoulder reconstruction ended his season prematurely.

Fought his way back to be selected for the Wallaby end of year tour and made his comeback in the Bledisloe Cup Test against the All Blacks in Tokyo.

[9][15] Ioane was suspended for 4 matches in 2012 while playing for the Reds, after making an illegal tackle on Sharks Flanker Marcell Coetzee.

[17] Ioane played an integral role in Australia's 3-0 Test series win over Wales in June 2012, and scored the vital match-winning try against Argentina in The 2012 Rugby Championship.

[18] Ioane moved to Europe at the end of 2013 on a two-season contract to play for Stade Français in the Top 14 French domestic competition.

Playing for the New Zealand-franchise club in the pool-game clash; he scoring a try against his former team: the Reds, guiding the Crusaders to the grand final (which however, they lost to the Chiefs).

Returning to Australia and making his Super Rugby debut for the Kiwi-club in Round 3 and playing against his good friend Quade Cooper and his former team: the Reds, Ioane producing an outstanding performance in the Crusaders' tight 22–20 win (with teammate Mitchell Hunt kicking a penalty goal in the 80th minute to win the game) at Suncorp Stadium.

Ioane (along with his former Wallabies teammate Berrick Barnes) was part of the Panasonic Wild Knights' squad for the 2018 Brisbane Global Rugby Tens tournament.